Sp3 Mediates Transcriptional Activation of the Leukocyte Integrin Genes CD11C and CD11B and Cooperates with c-Jun to Activate CD11C
نویسندگان
چکیده
منابع مشابه
Expressions of CD11a, CD11b, and CD11c integrin proteins in rats with myocardial hypertrophy
Objective(s):To examine the expressions of CD11a, CD11b, and CD11c integrins in the myocardial tissues of rats with isoproterenol-induced myocardial hypertrophy. This study also provided morphological data to investigate the signal transduction mechanisms of myocardial hypertrophy and reverse it. Materials and Methods: A myocardial hypertrophy model was established by subcutaneously injecting i...
متن کاملexpressions of cd11a, cd11b, and cd11c integrin proteins in rats with myocardial hypertrophy
objective(s):to examine the expressions of cd11a, cd11b, and cd11c integrins in the myocardial tissues of rats with isoproterenol-induced myocardial hypertrophy. this study also provided morphological data to investigate the signal transduction mechanisms of myocardial hypertrophy and reverse it. materials and methods: a myocardial hypertrophy model was established by subcutaneously injecting i...
متن کاملExpressions of CD11a, CD11b, and CD11c integrin proteins in rats with myocardial hypertrophy
OBJECTIVES To examine the expressions of CD11a, CD11b, and CD11c integrins in the myocardial tissues of rats with isoproterenol-induced myocardial hypertrophy. This study also provided morphological data to investigate the signal transduction mechanisms of myocardial hypertrophy and reverse it. MATERIALS AND METHODS A myocardial hypertrophy model was established by subcutaneously injecting is...
متن کاملSp1 cooperates with the ets transcription factor, GABP, to activate the CD18 (beta2 leukocyte integrin) promoter.
CD18, the beta chain of the leukocyte integrins, plays a crucial role in immune and inflammatory responses. CD18 is expressed exclusively by leukocytes, and it is transcriptionally regulated during the differentiation of myeloid cells. The ets factors, PU.1 and GABP, bind to three ets sites in the CD18 promoter, which are essential for high level myeloid expression of CD18. We now identify two ...
متن کاملBinding between the Integrin!X"2 (CD11c/CD18) and Heparin*
Thomas Vorup-Jensen, Lianli Chi, Louise C. Gjelstrup, Uffe B. Jensen, Craig A. Jewett, Can Xie, Motomu Shimaoka**, Robert J. Linhardt, and Timothy A. Springer From the Immune Disease Institute (formerly CBR Institute for Biomedical Research), Departments of Pathology and **Anesthesia, Harvard Medical School, Boston, Massachusetts 02115, the Biophysical Immunology Laboratory, Institute of Medica...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1997
ISSN: 0021-9258
DOI: 10.1074/jbc.272.38.24038